Coding

Part:BBa_K5238003:Design

Designed by: Yishi Jia   Group: iGEM24_NJMU-CHINA   (2024-07-10)


Produce inosine for the treatment of depression


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal EcoRI site found at 943
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal EcoRI site found at 943
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal EcoRI site found at 943
    Illegal BglII site found at 834
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal EcoRI site found at 943
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal EcoRI site found at 943
    Illegal AgeI site found at 663
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

https://www.ncbi.nlm.nih.gov/gene/15552358


Source

References: 1. Chen, P., Goldberg, D. E., Kolb, B., Lanser, M., & Benowitz, L. I. (2002). Inosine induces axonal rewiring and improves behavioral outcome after stroke. *Proceedings of the National Academy of Sciences*, 99(13), 9031-9036. 2. Walker, T. L., & Kempermann, G. (2014). One mouse, two cultures: isolating adult hippocampal neurogenesis in vitro. *Frontiers in Neuroscience*, 8, 384. 3. Sun, N., Qin, Y. J., Xu, C., et al. (2022). Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. *Science*, 378(6618), 390-398.

References